SNB-101 is innovative and exclusive core-shell shaped nano-micelle supplied by lyophilized IV formulation containing SN-38 (7-ethyl-10-hydroxycamtothecin), an active metabolite of prodrug IRINOTECAN (CAMTOSAR®, Pfizer).

SN-38 has 100~1,000 folds higher efficacy than irinotecan, but its low solubility limits its direct administration in the form of intravenous injection. Recently, Merrimack has succeeded dramatic increase of SN-38 from IRINOTECAN by long circulation formulation liposome(ONIVYDE®) to 30~40% compared with conventional IV formulation 2~8%.
Direct injection with "SN-38" formulation could be applied to "carboxyesterase II deficient tumors" such as pancreatic, lung, ovarian and prostate cancer. Carboxyesterase II is a converting enzyme from prodrug IRINOTECAN to active metabolite SN-38.

SNA-001 is protein-bound paclitaxel, also known as nano-particle albumin-bound paclitaxel (nab-paclitaxel), is an albumin-bound particle form of paclitaxel designed to utilize endogenous albumin pathways to increase intratumor concentrations of the active drug.